カテゴリー： Stratistics MRC, 世界, 部品/材料

治療用酵素の世界市場予測（～2027年）

◆英語タイトル：Therapeutics Enzymes Market Forecasts to 2028 – Global Analysis By Product Type (Chitinase, Asparginase and Other Product Types), By Application (Leukemia, Stomach Disorders and Other Applications), By End User (Drug manufacturers, Hospitals, Private clinics and Research laboratories) and Geography

Stratistics MRCが発行した調査報告書（SMR23MR052）◆商品コード：SMR23MR052
◆発行会社（リサーチ会社）：Stratistics MRC
◆発行日：2022年12月
◆ページ数：約150
◆レポート形式：英語 / Eメール
◆納品方法：英語
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◆産業分野：化学
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❖ レポートの概要 ❖

ストラティスティックスMRC社は、世界の治療用酵素市場規模が2022年8467.9百万ドルから2028年18684.8百万ドルになり、予測期間中に年平均14.1%で成長すると予測しています。本報告書では、治療用酵素の世界市場を調査し、エグゼクティブサマリー、序論、市場動向分析、ファイブフォース分析、製品種類別（キチナーゼ、アスパルギナーゼ、その他）分析、用途別（白血病、胃疾患、その他）分析、エンドユーザー別（製薬会社、病院、私立診療所、研究所）分析、地域別（北米、ヨーロッパ、アジア太平洋、南米、中東・アフリカ）分析、最近の動向、企業情報など、次のように掲載しています。また、企業情報としては、Sanofi, BioMarin, AbbVie, F. Hoffmann-La Roche Ltd,Thermo Fisher Scientific Inc., Alexion, DSM, Novozymes, Horizon Pharma, Allergan, Johnson and Johnson , Alexion Pharmaceuticals Inc, Pfizer Inc.などが含まれています。
・エグゼクティブサマリー
・序論
・市場動向分析
・ファイブフォース分析
・世界の治療用酵素市場規模：製品種類別
- キチナーゼの市場規模
- アスパルギナーゼの市場規模
- その他製品の市場規模
・世界の治療用酵素市場規模：用途別
- 白血病治療用酵素の市場規模
- 胃疾患治療用酵素の市場規模
- その他用途の市場規模
・世界の治療用酵素市場規模：エンドユーザー別
- 製薬会社における市場規模
- 病院における市場規模
- 私立診療所における市場規模
- 研究所における市場規模
・世界の治療用酵素市場規模：地域別
- 北米の治療用酵素市場規模
- ヨーロッパの治療用酵素市場規模
- アジア太平洋の治療用酵素市場規模
- 南米の治療用酵素市場規模
- 中東・アフリカの治療用酵素市場規模
・最近の動向
・企業情報

According to Stratistics MRC, the Global Therapeutic Enzymes Market is accounted for $8467.9 million in 2022 and is expected to reach $18684.8 million by 2028 growing at a CAGR of 14.1% during the forecast period. Enzymes and biocatalysts are produced in the human body from amino acids obtained from the digestion of food proteins. Therapeutic enzymes are a subset of enzymes that are used for medical purposes, either conjugated or isolated. These enzymes have a wide range of applications, including thrombolytics, oncolytics, anticoagulants, and replacements for certain metabolic deficiencies. Rising patient pool for leukaemia, other cancers, cardiovascular diseases, skin ulcers, and other diseases, increasing sedentary lifestyle responsible for increasing stress and subsequently giving rise to diseases, and improving healthcare services.

According to the American Cancer Society, 1,685,210 new cancer cases are expected to be diagnosed in the United States alone in 2016, while the World Health Organization reports that 17.7 million people died from cardiovascular diseases globally in 2015. This data demonstrates the market potential for cancer and cardiovascular therapeutics. Because therapeutic enzymes are important in the treatment of both diseases, their use is expected to increase over the forecast period.

Key players in the market

Some of the key players profiled in the Therapeutic Enzymes Market include Sanofi, BioMarin, AbbVie, F. Hoffmann-La Roche Ltd,Thermo Fisher Scientific Inc., Alexion, DSM, Novozymes, Horizon Pharma, Allergan, Johnson and Johnson , Alexion Pharmaceuticals Inc, Pfizer Inc., Vivus, Digestive Care, Leadiant Biosciences, Roche Holdings AG and Codexis Inc.

Key Developments:

In January 2020, Codexis and Nestlé Health Science entered into a strategic collaboration with an aim to discover new enzyme therapy for potential treatment for GI disorders.

In October 2018, Leadiant Biosciences, Inc. Received the USFDA approval for Revcovi, a enzyme replacement therapy for the treatment of adenosine deaminase severe combined immune deficiency (ADA-SCID) in pediatric and adult patients.

Product Types Covered:
• Chitinase
• Asparginase
• Lipase
• Protease
• Nattokinase
• Serratiopeptidase
• Collagenase
• Ligase
• Other Product Types

Applications Covered:
• Leukemia
• Stomach Disorders
• Antitumor
• Skin Ulcers
• Gaucher disease
• Fabry disease
• Other Applications

End Users Covered:
• Drug manufacturers
• Hospitals
• Private clinics
• Research laboratories

Regions Covered:
• North America
US
Canada
Mexico
• Europe
Germany
UK
Italy
France
Spain
Rest of Europe
• Asia Pacific
Japan
China
India
Australia
New Zealand
South Korea
Rest of Asia Pacific
• South America
Argentina
Brazil
Chile
Rest of South America
• Middle East & Africa
Saudi Arabia
UAE
Qatar
South Africa
Rest of Middle East & Africa

❖ レポートの目次 ❖

1 Executive Summary
2 Preface
2.1 Abstract
2.2 Stake Holders
2.3 Research Scope
2.4 Research Methodology
2.4.1 Data Mining
2.4.2 Data Analysis
2.4.3 Data Validation
2.4.4 Research Approach
2.5 Research Sources
2.5.1 Primary Research Sources
2.5.2 Secondary Research Sources
2.5.3 Assumptions
3 Market Trend Analysis
3.1 Introduction
3.2 Drivers
3.3 Restraints
3.4 Opportunities
3.5 Threats
3.6 Product Analysis
3.7 Application Analysis
3.8 End User Analysis
3.9 Emerging Markets
3.10 Impact of Covid-19
4 Porters Five Force Analysis
4.1 Bargaining power of suppliers
4.2 Bargaining power of buyers
4.3 Threat of substitutes
4.4 Threat of new entrants
4.5 Competitive rivalry
5 Global Therapeutic Enzymes Market, By Product Type
5.1 Introduction
5.2 Chitinase
5.3 Asparginase
5.4 Lipase
5.5 Protease
5.6 Nattokinase
5.7 Serratiopeptidase
5.8 Collagenase
5.9 Ligase
5.10 Other Product Types
6 Global Therapeutic Enzymes Market, By Application
6.1 Introduction
6.2 Leukemia
6.3 Stomach Disorders
6.4 Antitumor
6.5 Skin Ulcers
6.6 Gaucher disease
6.7 Fabry disease
6.8 Other Applications
7 Global Therapeutic Enzymes Market, End User
7.1 Introduction
7.2 Drug manufacturers
7.3 Hospitals
7.4 Private clinics
7.5 Research laboratories
8 Global Therapeutic Enzymes Market, By Geography
8.1 Introduction
8.2 North America
8.2.1 US
8.2.2 Canada
8.2.3 Mexico
8.3 Europe
8.3.1 Germany
8.3.2 UK
8.3.3 Italy
8.3.4 France
8.3.5 Spain
8.3.6 Rest of Europe
8.4 Asia Pacific
8.4.1 Japan
8.4.2 China
8.4.3 India
8.4.4 Australia
8.4.5 New Zealand
8.4.6 South Korea
8.4.7 Rest of Asia Pacific
8.5 South America
8.5.1 Argentina
8.5.2 Brazil
8.5.3 Chile
8.5.4 Rest of South America
8.6 Middle East & Africa
8.6.1 Saudi Arabia
8.6.2 UAE
8.6.3 Qatar
8.6.4 South Africa
8.6.5 Rest of Middle East & Africa
9 Key Developments
9.1 Agreements, Partnerships, Collaborations and Joint Ventures
9.2 Acquisitions & Mergers
9.3 New Product Launch
9.4 Expansions
9.5 Other Key Strategies
10 Company Profiling
10.1 Sanofi
10.2 BioMarin
10.3 AbbVie
10.4 F. Hoffmann-La Roche Ltd
10.5 Thermo Fisher Scientific Inc.
10.6 Alexion
10.7 DSM
10.8 Novozymes
10.9 Horizon Pharma
10.10 Allergan
10.11 Johnson and Johnson
10.12 Alexion Pharmaceuticals Inc
10.13 Pfizer Inc.
10.14 Vivus, Digestive Care
10.15 Leadiant Biosciences
10.16 Roche Holdings AG
10.17 Codexis Inc.
List of Tables
Table 1 Global Therapeutic Enzymes Market Outlook, By Region (2020-2028) ($MN)
Table 2 Global Therapeutic Enzymes Market Outlook, By Product Type (2020-2028) ($MN)
Table 3 Global Therapeutic Enzymes Market Outlook, By Chitinase (2020-2028) ($MN)
Table 4 Global Therapeutic Enzymes Market Outlook, By Asparginase (2020-2028) ($MN)
Table 5 Global Therapeutic Enzymes Market Outlook, By Lipase (2020-2028) ($MN)
Table 6 Global Therapeutic Enzymes Market Outlook, By Protease (2020-2028) ($MN)
Table 7 Global Therapeutic Enzymes Market Outlook, By Nattokinase (2020-2028) ($MN)
Table 8 Global Therapeutic Enzymes Market Outlook, By Serratiopeptidase (2020-2028) ($MN)
Table 9 Global Therapeutic Enzymes Market Outlook, By Collagenase (2020-2028) ($MN)
Table 10 Global Therapeutic Enzymes Market Outlook, By Ligase (2020-2028) ($MN)
Table 11 Global Therapeutic Enzymes Market Outlook, By Other Product Types (2020-2028) ($MN)
Table 12 Global Therapeutic Enzymes Market Outlook, By Application (2020-2028) ($MN)
Table 13 Global Therapeutic Enzymes Market Outlook, By Leukemia (2020-2028) ($MN)
Table 14 Global Therapeutic Enzymes Market Outlook, By Stomach Disorders (2020-2028) ($MN)
Table 15 Global Therapeutic Enzymes Market Outlook, By Antitumor (2020-2028) ($MN)
Table 16 Global Therapeutic Enzymes Market Outlook, By Skin Ulcers (2020-2028) ($MN)
Table 17 Global Therapeutic Enzymes Market Outlook, By Gaucher disease (2020-2028) ($MN)
Table 18 Global Therapeutic Enzymes Market Outlook, By Fabry disease (2020-2028) ($MN)
Table 19 Global Therapeutic Enzymes Market Outlook, By Other Application (2020-2028) ($MN)
Table 20 Global Therapeutic Enzymes Market Outlook, By End User (2020-2028) ($MN)
Table 21 Global Therapeutic Enzymes Market Outlook, By Drug manufacturers (2020-2028) ($MN)
Table 22 Global Therapeutic Enzymes Market Outlook, By Hospitals (2020-2028) ($MN)
Table 23 Global Therapeutic Enzymes Market Outlook, By Private clinics (2020-2028) ($MN)
Table 24 Global Therapeutic Enzymes Market Outlook, By Research laboratories (2020-2028) ($MN)
Table 25 North America Therapeutic Enzymes Market Outlook, By Country (2020-2028) ($MN)
Table 26 North America Therapeutic Enzymes Market Outlook, By Product Type (2020-2028) ($MN)
Table 27 North America Therapeutic Enzymes Market Outlook, By Chitinase (2020-2028) ($MN)
Table 28 North America Therapeutic Enzymes Market Outlook, By Asparginase (2020-2028) ($MN)
Table 29 North America Therapeutic Enzymes Market Outlook, By Lipase (2020-2028) ($MN)
Table 30 North America Therapeutic Enzymes Market Outlook, By Protease (2020-2028) ($MN)
Table 31 North America Therapeutic Enzymes Market Outlook, By Nattokinase (2020-2028) ($MN)
Table 32 North America Therapeutic Enzymes Market Outlook, By Serratiopeptidase (2020-2028) ($MN)
Table 33 North America Therapeutic Enzymes Market Outlook, By Collagenase (2020-2028) ($MN)
Table 34 North America Therapeutic Enzymes Market Outlook, By Ligase (2020-2028) ($MN)
Table 35 North America Therapeutic Enzymes Market Outlook, By Other Product Types (2020-2028) ($MN)
Table 36 North America Therapeutic Enzymes Market Outlook, By Application (2020-2028) ($MN)
Table 37 North America Therapeutic Enzymes Market Outlook, By Leukemia (2020-2028) ($MN)
Table 38 North America Therapeutic Enzymes Market Outlook, By Stomach Disorders (2020-2028) ($MN)
Table 39 North America Therapeutic Enzymes Market Outlook, By Antitumor (2020-2028) ($MN)
Table 40 North America Therapeutic Enzymes Market Outlook, By Skin Ulcers (2020-2028) ($MN)
Table 41 North America Therapeutic Enzymes Market Outlook, By Gaucher disease (2020-2028) ($MN)
Table 42 North America Therapeutic Enzymes Market Outlook, By Fabry disease (2020-2028) ($MN)
Table 43 North America Therapeutic Enzymes Market Outlook, By Other Application (2020-2028) ($MN)
Table 44 North America Therapeutic Enzymes Market Outlook, By End User (2020-2028) ($MN)
Table 45 North America Therapeutic Enzymes Market Outlook, By Drug manufacturers (2020-2028) ($MN)
Table 46 North America Therapeutic Enzymes Market Outlook, By Hospitals (2020-2028) ($MN)
Table 47 North America Therapeutic Enzymes Market Outlook, By Private clinics (2020-2028) ($MN)
Table 48 North America Therapeutic Enzymes Market Outlook, By Research laboratories (2020-2028) ($MN)
Table 49 Europe Therapeutic Enzymes Market Outlook, By Country (2020-2028) ($MN)
Table 50 Europe Therapeutic Enzymes Market Outlook, By Product Type (2020-2028) ($MN)
Table 51 Europe Therapeutic Enzymes Market Outlook, By Chitinase (2020-2028) ($MN)
Table 52 Europe Therapeutic Enzymes Market Outlook, By Asparginase (2020-2028) ($MN)
Table 53 Europe Therapeutic Enzymes Market Outlook, By Lipase (2020-2028) ($MN)
Table 54 Europe Therapeutic Enzymes Market Outlook, By Protease (2020-2028) ($MN)
Table 55 Europe Therapeutic Enzymes Market Outlook, By Nattokinase (2020-2028) ($MN)
Table 56 Europe Therapeutic Enzymes Market Outlook, By Serratiopeptidase (2020-2028) ($MN)
Table 57 Europe Therapeutic Enzymes Market Outlook, By Collagenase (2020-2028) ($MN)
Table 58 Europe Therapeutic Enzymes Market Outlook, By Ligase (2020-2028) ($MN)
Table 59 Europe Therapeutic Enzymes Market Outlook, By Other Product Types (2020-2028) ($MN)
Table 60 Europe Therapeutic Enzymes Market Outlook, By Application (2020-2028) ($MN)
Table 61 Europe Therapeutic Enzymes Market Outlook, By Leukemia (2020-2028) ($MN)
Table 62 Europe Therapeutic Enzymes Market Outlook, By Stomach Disorders (2020-2028) ($MN)
Table 63 Europe Therapeutic Enzymes Market Outlook, By Antitumor (2020-2028) ($MN)
Table 64 Europe Therapeutic Enzymes Market Outlook, By Skin Ulcers (2020-2028) ($MN)
Table 65 Europe Therapeutic Enzymes Market Outlook, By Gaucher disease (2020-2028) ($MN)
Table 66 Europe Therapeutic Enzymes Market Outlook, By Fabry disease (2020-2028) ($MN)
Table 67 Europe Therapeutic Enzymes Market Outlook, By Other Application (2020-2028) ($MN)
Table 68 Europe Therapeutic Enzymes Market Outlook, By End User (2020-2028) ($MN)
Table 69 Europe Therapeutic Enzymes Market Outlook, By Drug manufacturers (2020-2028) ($MN)
Table 70 Europe Therapeutic Enzymes Market Outlook, By Hospitals (2020-2028) ($MN)
Table 71 Europe Therapeutic Enzymes Market Outlook, By Private clinics (2020-2028) ($MN)
Table 72 Europe Therapeutic Enzymes Market Outlook, By Research laboratories (2020-2028) ($MN)
Table 73 Asia Pacific Therapeutic Enzymes Market Outlook, By Country (2020-2028) ($MN)
Table 74 Asia Pacific Therapeutic Enzymes Market Outlook, By Product Type (2020-2028) ($MN)
Table 75 Asia Pacific Therapeutic Enzymes Market Outlook, By Chitinase (2020-2028) ($MN)
Table 76 Asia Pacific Therapeutic Enzymes Market Outlook, By Asparginase (2020-2028) ($MN)
Table 77 Asia Pacific Therapeutic Enzymes Market Outlook, By Lipase (2020-2028) ($MN)
Table 78 Asia Pacific Therapeutic Enzymes Market Outlook, By Protease (2020-2028) ($MN)
Table 79 Asia Pacific Therapeutic Enzymes Market Outlook, By Nattokinase (2020-2028) ($MN)
Table 80 Asia Pacific Therapeutic Enzymes Market Outlook, By Serratiopeptidase (2020-2028) ($MN)
Table 81 Asia Pacific Therapeutic Enzymes Market Outlook, By Collagenase (2020-2028) ($MN)
Table 82 Asia Pacific Therapeutic Enzymes Market Outlook, By Ligase (2020-2028) ($MN)
Table 83 Asia Pacific Therapeutic Enzymes Market Outlook, By Other Product Types (2020-2028) ($MN)
Table 84 Asia Pacific Therapeutic Enzymes Market Outlook, By Application (2020-2028) ($MN)
Table 85 Asia Pacific Therapeutic Enzymes Market Outlook, By Leukemia (2020-2028) ($MN)
Table 86 Asia Pacific Therapeutic Enzymes Market Outlook, By Stomach Disorders (2020-2028) ($MN)
Table 87 Asia Pacific Therapeutic Enzymes Market Outlook, By Antitumor (2020-2028) ($MN)
Table 88 Asia Pacific Therapeutic Enzymes Market Outlook, By Skin Ulcers (2020-2028) ($MN)
Table 89 Asia Pacific Therapeutic Enzymes Market Outlook, By Gaucher disease (2020-2028) ($MN)
Table 90 Asia Pacific Therapeutic Enzymes Market Outlook, By Fabry disease (2020-2028) ($MN)
Table 91 Asia Pacific Therapeutic Enzymes Market Outlook, By Other Application (2020-2028) ($MN)
Table 92 Asia Pacific Therapeutic Enzymes Market Outlook, By End User (2020-2028) ($MN)
Table 93 Asia Pacific Therapeutic Enzymes Market Outlook, By Drug manufacturers (2020-2028) ($MN)
Table 94 Asia Pacific Therapeutic Enzymes Market Outlook, By Hospitals (2020-2028) ($MN)
Table 95 Asia Pacific Therapeutic Enzymes Market Outlook, By Private clinics (2020-2028) ($MN)
Table 96 Asia Pacific Therapeutic Enzymes Market Outlook, By Research laboratories (2020-2028) ($MN)
Table 97 South America Therapeutic Enzymes Market Outlook, By Country (2020-2028) ($MN)
Table 98 South America Therapeutic Enzymes Market Outlook, By Product Type (2020-2028) ($MN)
Table 99 South America Therapeutic Enzymes Market Outlook, By Chitinase (2020-2028) ($MN)
Table 100 South America Therapeutic Enzymes Market Outlook, By Asparginase (2020-2028) ($MN)
Table 101 South America Therapeutic Enzymes Market Outlook, By Lipase (2020-2028) ($MN)
Table 102 South America Therapeutic Enzymes Market Outlook, By Protease (2020-2028) ($MN)
Table 103 South America Therapeutic Enzymes Market Outlook, By Nattokinase (2020-2028) ($MN)
Table 104 South America Therapeutic Enzymes Market Outlook, By Serratiopeptidase (2020-2028) ($MN)
Table 105 South America Therapeutic Enzymes Market Outlook, By Collagenase (2020-2028) ($MN)
Table 106 South America Therapeutic Enzymes Market Outlook, By Ligase (2020-2028) ($MN)
Table 107 South America Therapeutic Enzymes Market Outlook, By Other Product Types (2020-2028) ($MN)
Table 108 South America Therapeutic Enzymes Market Outlook, By Application (2020-2028) ($MN)
Table 109 South America Therapeutic Enzymes Market Outlook, By Leukemia (2020-2028) ($MN)
Table 110 South America Therapeutic Enzymes Market Outlook, By Stomach Disorders (2020-2028) ($MN)
Table 111 South America Therapeutic Enzymes Market Outlook, By Antitumor (2020-2028) ($MN)
Table 112 South America Therapeutic Enzymes Market Outlook, By Skin Ulcers (2020-2028) ($MN)
Table 113 South America Therapeutic Enzymes Market Outlook, By Gaucher disease (2020-2028) ($MN)
Table 114 South America Therapeutic Enzymes Market Outlook, By Fabry disease (2020-2028) ($MN)
Table 115 South America Therapeutic Enzymes Market Outlook, By Other Application (2020-2028) ($MN)
Table 116 South America Therapeutic Enzymes Market Outlook, By End User (2020-2028) ($MN)
Table 117 South America Therapeutic Enzymes Market Outlook, By Drug manufacturers (2020-2028) ($MN)
Table 118 South America Therapeutic Enzymes Market Outlook, By Hospitals (2020-2028) ($MN)
Table 119 South America Therapeutic Enzymes Market Outlook, By Private clinics (2020-2028) ($MN)
Table 120 South America Therapeutic Enzymes Market Outlook, By Research laboratories (2020-2028) ($MN)
Table 121 Middle East & Africa Therapeutic Enzymes Market Outlook, By Country (2020-2028) ($MN)
Table 122 Middle East & Africa Therapeutic Enzymes Market Outlook, By Product Type (2020-2028) ($MN)
Table 123 Middle East & Africa Therapeutic Enzymes Market Outlook, By Chitinase (2020-2028) ($MN)
Table 124 Middle East & Africa Therapeutic Enzymes Market Outlook, By Asparginase (2020-2028) ($MN)
Table 125 Middle East & Africa Therapeutic Enzymes Market Outlook, By Lipase (2020-2028) ($MN)
Table 126 Middle East & Africa Therapeutic Enzymes Market Outlook, By Protease (2020-2028) ($MN)
Table 127 Middle East & Africa Therapeutic Enzymes Market Outlook, By Nattokinase (2020-2028) ($MN)
Table 128 Middle East & Africa Therapeutic Enzymes Market Outlook, By Serratiopeptidase (2020-2028) ($MN)
Table 129 Middle East & Africa Therapeutic Enzymes Market Outlook, By Collagenase (2020-2028) ($MN)
Table 130 Middle East & Africa Therapeutic Enzymes Market Outlook, By Ligase (2020-2028) ($MN)
Table 131 Middle East & Africa Therapeutic Enzymes Market Outlook, By Other Product Types (2020-2028) ($MN)
Table 132 Middle East & Africa Therapeutic Enzymes Market Outlook, By Application (2020-2028) ($MN)
Table 133 Middle East & Africa Therapeutic Enzymes Market Outlook, By Leukemia (2020-2028) ($MN)
Table 134 Middle East & Africa Therapeutic Enzymes Market Outlook, By Stomach Disorders (2020-2028) ($MN)
Table 135 Middle East & Africa Therapeutic Enzymes Market Outlook, By Antitumor (2020-2028) ($MN)
Table 136 Middle East & Africa Therapeutic Enzymes Market Outlook, By Skin Ulcers (2020-2028) ($MN)
Table 137 Middle East & Africa Therapeutic Enzymes Market Outlook, By Gaucher disease (2020-2028) ($MN)
Table 138 Middle East & Africa Therapeutic Enzymes Market Outlook, By Fabry disease (2020-2028) ($MN)
Table 139 Middle East & Africa Therapeutic Enzymes Market Outlook, By Other Application (2020-2028) ($MN)
Table 140 Middle East & Africa Therapeutic Enzymes Market Outlook, By End User (2020-2028) ($MN)
Table 141 Middle East & Africa Therapeutic Enzymes Market Outlook, By Drug manufacturers (2020-2028) ($MN)
Table 142 Middle East & Africa Therapeutic Enzymes Market Outlook, By Hospitals (2020-2028) ($MN)
Table 143 Middle East & Africa Therapeutic Enzymes Market Outlook, By Private clinics (2020-2028) ($MN)
Table 144 Middle East & Africa Therapeutic Enzymes Market Outlook, By Research laboratories (2020-2028) ($MN)



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